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Augmenting Language Interventions for ASD: A Translational Approach

Location: Los Angeles, CA

Researchers at the UCLA Division of Child and Adolescent Psychiatry are conducting a research study to examine the combined effects of a behavioral intervention and medication on language development in children with autism.



Brain Function in Neurotypical and Neuroatypical Populations

The goal of this study is to model dynamic brain function during both rest and task related states. Of particular interest is the comparison of brain activity across simple cognitive tasks and populations.

 Location: Newark, NJ :  http://rubic.rutgers.edu/BD2K.php



Nicotinic Cholinergic Modulation as a Novel Treatment Strategy for Aggression Associated With Autism

Some individuals with autism spectrum disorders (ASD) also demonstrate irritability or aggression, which can interfere with functioning. The purpose of this pilot study is to test whether transdermal nicotine is effective for irritability and/or aggression in adults with ASD using a double-blind, placebo-controlled clinical trial. Subjects will participate in three visits. At the first visit, subjects are screened for eligibility and enrolled. Baseline measures include rating scales and a frustrative computerized task. They will then wear seven days of transdermal nicotine or placebo. Visit two is on day seven and the study measures are repeated, vital signs and side effects monitored. Subjects will return for a third and final visit on day 21 to repeat the study measures performed during visit two.

Location:  Yale Child Study Center and Connecticut Mental Health Center, New Haven, Connecticut

 



SPARK: Simons (Foundation) Powering Autism Research for Knowledge
An online initiative designed to engage 50,000 people with autism and their families in autism research. Participants will have the opportunity to contribute a DNA saliva sample for analysis along with medical and behavioral information.

Language Development in Boys with Autism and Boys with Fragile X Syndrome

Location: The study is being conducted at the Waisman Center at the University of Wisconsin-Madison. Travel accommodations, including airfare and hotel stay, will be paid for and arranged by the project.

The purpose of the study is to learn more about how boys with autism and boys with fragile X syndrome use language in a variety of contexts. We are also interested in the best way to assess language abilities (e.g., conversation, standardized tests). The results will inform Speech Language Pathologists who need to make accurate and appropriate assessments of language abilities to identify targets for treatment.



A Double Blind, Randomized, Placebo-Controlled Study of CM-AT for the Treatment of Autism in Children With All Levels of Fecal Chymotrypsin (FCT)

The purpose of this study is to determine whether CM-AT is safe and effective in treating the core symptoms of autism in children with all levels of fecal chymotrypsin.

Locations: Arizona, Arkansas, California, Connecticut, Florida, Louisiana, Michigan, New Mexico, New York, North Carolina, Ohio, Rhode Island, Tennessee, Texas, Utah, Virginia



Marital Satisfaction and Autism: Perceived Symptom Severity and Gender DIfferences

In this research study, the aim is to investigate the relationship between autism symptom severity and the level of marital satisfaction for parents with an ASD child. This will be based on data collected in self-report questionnaires that ask about marital satisfaction and how each parent perceives the severity of their child’s autistic symptoms. The study will also take into account gender differences between male and female based responses to the questionnaires. 

Location: Questionnaire 



Social processing in typical development and autism spectrum disorder

This is a research project being conducted by Professor Elizabeth Redcay at the University of Maryland, College Park. The primary goal of this research is to understand the brain and behavioral bases of social processing in typical and atypical development. Our approach to achieving this goal will include a combination of behavioral and neuroimaging measures (e.g., functional MRI).

location: College Park, MD



Language, Communication, and Brain Development

Dr. lnge-Marie Eigsti from the Department of Psychological Sciences at UConn is doing research on communication abilities. We are enrolling adults ages 18-35 with Autism Spectrum Disorders. What's involved? You'll spend a few hours playing games and doing tasks involving language, memory, and problem-solving on the Storrs UConn campus. You will be compensated $10 per hour for your time. Participants will have an opportunity to participate in a brain imaging study, which pays $40 per hour.

location: University of Connecticut, Storrs, CT


Survey of Young Adults’ Identity and Personal Characteristics

The purpose of this study is to develop a deeper understanding of young adults who either have or do not have an autism spectrum disorder, by learning more about their self-perceptions, perceptions of and concern for others, and responses in specific situations.

 Location: Online Survey 



New Autism Trial for Children with Autism 3-8 Years of Age

Investigators at the Duke Center for Autism and Brain Development are studying an investigational medication in children with Autistic Disorder. If they meet inclusion criteria, they will be given the investigational medication CM-AT, or placebo (fake medicine).

Investigators want to see if the study medication may help improve some of the symptoms that are often associated with autism such as irritability. Researchers will evaluate children using psychological, psychiatric, medical, behavioral, and developmental measures. Children who meet eligibility criteria will have the opportunity to enroll in a 12-week clinical trial in which they will receive a powdered investigational medicine or a placebo (a powder containing no active medicine). This trial will be followed by an open-label trial so everyone gets to try the investigational medication. This medication is not approved by the United States Food and Drug Administration.

The study involves visits in person visits every two weeks for the duration of the study at our center. Participants will be provided with free and convenient parking. Research related services and medication will be free of charge. Participants will be compensated for their participation.

Location: 

The Duke Center for Autism and Brain Development

2608 Erwin Road, Suite 300

Durham, NC 27705


Study on Access to Clinical Resources for Patients with Genetic and Neurodevelopmental Disorders
The purpose of this study is to investigate access to clinical care and clinical research for patients with genetic and
neurodevelopmental disorders. This research will entail an anonymous online survey sent to families/caretakers of children with
genetic and neurodevelopmental disorders. The survey will inquire: (1) basic clinical information about the child, such as diagnoses
(both genetic and neurodevelopmental), level of functioning (estimated IQ) (2) clinical specialists that the child sees or needs to
see (3) how families learn about clinical trials/research relevant to their child; and (4) basic demographics about the
parent/caretaker completing the survey.
The purpose of this study is to investigate access to clinical care and clinical research for patients with genetic and
neurodevelopmental disorders. This research will entail an anonymous online survey sent to families/caretakers of children with
genetic and neurodevelopmental disorders. The survey will inquire: (1) basic clinical information about the child, such as diagnoses
(both genetic and neurodevelopmental), level of functioning (estimated IQ) (2) clinical specialists that the child sees or needs to
see (3) how families learn about clinical trials/research relevant to their child; and (4) basic demographics about the
parent/caretaker completing the survey.


Location: Johns Hopkins, Kennedy Krieger Institute



A Longitudinal MRI Study of Infants At-Risk for Autism: Infant Brain Imaging Study

The University of Washington is part of a large multi-site national study which aims to learn more about brain development in young siblings of children with autism spectrum disorders (ASD). The information gained in this study may improve methods of early detection, improve intervention for infants who may be at risk for developing autism, and lead to better outcomes for young children and their families. Participants will receive developmental assessments and Magnetic Resonance Imaging (MRI) scans four times between 3 and 24 months, as well as one follow-up developmental assessment after 36 months.

Location(s):

  • University of Washington,  Seattle, WA
  • University of North Carolina, Chapel Hill, NC
  • Washington University, St. Louis, MO
  • Children’s Hospital of Philadelphia, Philadelphia, PA

 



Autism Treatment Effectiveness Survey

Conduct a national/international survey to evaluate the effectiveness and possible side-effects of treatments for autism, including medications, nutritional supplements, diets, therapies, and education.

Location(s):  US and international



Joint Attention Mediated Learning Intervention for Toddlers with Autism Spectrum Disorders and Their Families

Location: North Carolina

The purpose of this study is to test a home-based, parent delivered intervention for toddlers who may have an autism spectrum disorder.



Vulnerability of individuals with autism spectrum disorder to naïve involvement in criminal activity

Location: Online Survey

The aim of this project is to understand whether features that may be present in individuals diagnosed with autism spectrum disorder influence their understanding of social situations and appropriate behaviour. If the relationship between ASD and offending is better understood, employees within the criminal justice system, including judges, juries, and magistrates may be able to make more informed decisions regarding the behaviour of individuals with the disorder who offend (Freckelton & List, 2009; Mouridsen, 2012).



Autism Spectrum Disorder Severity and Lifestyles

The purpose of the study is to attempt to find a link between severity of Autism Spectrum Disorder symptoms and various lifestyle habits. Specifically, the link between sleeping positions and Autism Symptoms will be investigated.

Location(s): Online

 



Brain Connectivity in Neurotypical and Neuroatypical Populations

The goal of this research is to examine the connectivity or interaction of brain areas when an individual is engaged in a task and when that individual is not engaged in any particular task (a resting state). Brain activity will be recorded in an MRI scanner while the participant engages in simple tasks or “rests.” The fMRI data will be analyzed to determine how various brain areas interact under task and rest conditions with a particular focus on comparisons across tasks and across subject populations (neurotypical, schizophrenia, and autism).

Location

Rutgers University Brain Imaging Center (RUBIC)

197 University Ave, Aidekman Building

Newark, NJ 07102



Toddlers with Autism: Developing Opportunities for Learning (TADPOLE)

Location: Seattle, WA

The purpose of this study is to evaluate the effects of intensity of treatment and delivery style on the developmental progress of young children with ASD. To do this, researchers at the University of Washington, Vanderbilt Kennedy Center, and MIND Institute are comparing two versions of one-on-one early intervention for young children with autism: One play-based (ESDM), and one structured, table-top-based (DTT, discrete trial training). Qualifying toddlers who show signs of autism receive one year of in-home intervention and parent coaching, as well as developmental follow-ups throughout the year.



Joint Engagement in Infants at Risk for ASD: Integrating

Location: UCLA

This "Baby JASPER" study uses a historically successful parent-mediated intervention to address the autism-specific social and communicative delays in infants, and uses active models of adult learning to achieve these effects, which may result in better child developmental outcomes. The intervention model (a) targets the foundations of social-communication (joint attention, imitation, play), (b) uses naturalistic strategies to increase the rate and complexity of socialcommunication and (c) includes parents as implementers of the intervention to promote generalization across settings and activities and to ensure maintenance over time.



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