Dana-Farber Leadership Council
Table of Contents:

A Message from Your Co-Chairs

The first half of 2013 has been busy for the Leadership Council! As of July 31, the Council has raised more than $293,000 towards our goal of $610,000 and added nine new members. Your gifts are truly appreciated, whether you are making a gift to support the Institute or volunteering or participating in an event. Thank you for your time and support!

We'd like to take a moment to note a few leadership changes. Sarah Molloy Roxe has stepped down as Co-Chair of the Outreach Committee. We thank Sarah for her service and welcome Henry Cataldo as the new Outreach Co-Chair. Jamie Brown has stepped down as Co-Chair of the Walk Committee. We are grateful for Jamie's leadership and glad to have Rachel Pearson on board as the new Walk Co-Chair.

Fahey FamilyWe would also like to recognize the generosity of DFLC member, Larry Fahey, and his wife, Gail, who recently made a gift to name a nourishment area in the Yawkey Center for Cancer Care. There are so many ways to make an impact on the future of cancer at the Institute, and we are grateful that Larry and Gail have chosen to make this enduring commitment.

This fall we are excited to introduce our second Dana-Farber Leadership Council Fellow. This is an annual funding opportunity to provide current use support for a current DFCI trainee. This year's DFLC Fellow is Marios Giannakis, MD, PhD. Read more about him in this newsletter and hear about his exciting research in person at the Fall Social September 5.

Enjoy the last few weeks of summer! Be sure to mark your calendars for the DFLC Fall Social September 5, the 25th Annual Boston Marathon® Jimmy Fund Walk September 8, and the DFLC Fall Gathering November 7. Don't forget to bring a friend; we are always looking for new members!

All the best,

Jeff Goldstein & Russell Norris

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Save the Date

September 5, 2013 DFLC Fall Social
6:00 – 8:00 p.m.
The Algonquin Club of Boston

The Algonquin Club of BostonMark your calendars for Thursday, September 5 for the DFLC Fall Social at The Algonquin Club of Boston for a cocktail reception and the kickoff of the second annual Dana-Farber Leadership Council fellowship initiative!

The Algonquin Club of Boston is a unique and beautiful space designed by McKim, Mead & White, completed in 1888, and soon thereafter called "the finest and most perfectly appointed clubhouse in America." It remains the only Boston club with a purpose-built clubhouse. We are very grateful to Eaton Vance and Webster Bank for hosting this event for the second year in a row.

Dr. Marios GiannakisDana-Farber Leadership Council Fellow Marios Giannakis, MD, PhD, is a Fellow in Medical Oncology at Dana-Farber/Partners Cancer Care and a post-doctoral fellow in the lab of Levi Garraway MD, PhD. His research focuses on cancer genomics, novel therapies using chromatin modifying agents and identifying predictors of response to cancer immunotherapies.

Expanding the range of therapeutics to include chromatin modifier drugs can lead to more effective treatments for cancer patients with certain mutations, and predictors will tell us who can benefit the most from immunotherapies.

Giannakis earned a BSc in Molecular Biology and Molecular Genetics from the University of Toronto. After being awarded his MD and PhD degrees from the Washington University School of Medicine, Giannakis completed a residency in internal medicine at Brigham and Women's Hospital.

September 8, 2013 Boston Marathon® Jimmy Fund Walk Boston Marathon® Jimmy Fund Walk presented by Hyundai
The DFLC Walk Committee invites you to participate in the 25th Annual Boston Marathon® Jimmy Fund Walk Sunday, September 8, 2013. Join members of the DFLC Walk team and help us set new records this year! Our team goal is to register more than 25 walkers and raise $25,000 for Dana-Farber. Choose from the 3, 5, 13.1, and 26.2 mile route options and enjoy great food and entertainment throughout the day. Busy on Walk day? Show your support for the DFLC team and sign up to participate as a Virtual Walker, volunteer, or make a gift to the team!

For more information, please contact Sarah Dillon at 617-632-6434 or visit JimmyFundWalk.org.

November 7, 2013 DFLC Fall Gathering
Dana-Farber Cancer Institute, Boston

Mark your calendars to join us Thursday, November 7 for the DFLC Fall Gathering at Dana-Farber Cancer Institute in Boston. More details to come!

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New Member Spotlight

Henry CataldoHenry Cataldo
Place of Birth: Born in Worcester, MA; raised in Faribault, MN
Attended: Bentley University, Waltham
Lives in: Seaport District, Boston
Workplace and Title: Senior Associate; Provident Healthcare Partners
Favorite Boston restaurant: Sushi at Legal Harborside or anything from the good people at Life Alive in Cambridge
In my free time I am most likely: Outside, doing any and all things "active"
I joined DFLC because: I very much admire and appreciate the way Dana-Farber affects people's lives for the better and strongly believe I can be an asset in improving its visibility, awareness, and engagement through the DFLC.

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Committee Corner

Outreach Committee–Co-chairs: Henry Cataldo and Andy Fay
The Outreach Committee is thrilled that nine new members have joined the Council since January. Please continue to refer friends and co-workers! For information about membership or to get more involved with any of the sub-committees please send a message to leadership_council@dfci.harvard.edu.

Annual Giving Committee–Co-chairs: Jeff Beale and Ted Simms
The Annual Giving Committee will be hosting its annual Phonathon at Eaton Vance September 12. All members are welcome to attend this rewarding and fun evening to call fellow DFLC members to ask for their renewed support of Dana-Farber. For more information, please contact Erin Northrop at 617-582-7491.

As of July 31, 41 members of the Council have contributed $95,722 to the Annual Fund. The Council is striving to meet its goal of $270,000 with 100% participation by the end of the calendar year. A gift to the Annual Fund in any amount is now a DFLC membership requirement. The Annual Giving Committee would like to recognize the members listed below for their Annual Fund gifts (January 1–July 31). All 2013 gifts made to the Annual Fund will be acknowledged in the Winter 2014 e-newsletter.

Jeff Beale
Jamie Brown
Mark Burkhard
David Capelle
Jamie Chafel
Sara Cohn
Russell Curtis
Peter Devlin
Debra Drapalla
Shane & Joseph Estock
Larry Fahey
Sean Fairley
Andrew Fay
Jeffrey Feingold
Trudi Feinstein

Bill Gillen*
Jeff Goldstein
Matthew Goldstein
Beth Grazio
Brian Higgins
Sean Kelly
Karen Kiffney
Andrew Kiley
Mike Libert
Eric Marandett
John Murphy
Nancy O'Brien
Cynthia O'Brien
Jessica Radford
Sarah Roxe

Jodie & Scott Sadowsky
John Shea
Ted Simms
Darby Stott
Amy Sullivan
Neil Sullivan
Brian Taranto
Kathy Washburn
Jim Weis
Abby Witkin
Marc Zwetchkenbaum

* Dana-Farber Trustee

Boston Marathon® Jimmy Fund Walk Walk Committee–Co-chairs: Ian McLeod and Rachel Pearson
We're gearing up for another successful Boston Marathon® Jimmy Fund Walk. On September 8, we'll join thousands of walkers in the quest to conquer cancer. The DFLC team currently has ten members with a goal to raise $25,000 for the Walk's 25th Anniversary. If you're interested in walking with us, please visit our DFLC team page and register today!

For more information, contact Ian McLeod or Rachel Pearson.

Jimmy Fund GolfGolf Committee–Co-chairs: Sean Fairley and Brian Taranto
Raising a record $93,000, the 10th Annual Dana-Farber Leadership Council Golf Tournament took place June 19 at Granite Links. The tournament grew its fundraising by more than 50% from last year! Congratulations to the entire Golf Committee on executing an incredibly successful event. Following a great day on the course, the evening program included a special message from a very meaningful family speaker. Longtime Council member Jim Weis shared his family's story of battling cancer alongside his late wife Deirdre, a Dana-Farber patient.

Sincere thanks go out to all tournament sponsors, especially co-title sponsors Eaton Vance and LeapFrog Systems. Learn more about the tournament and view a list of all sponsors.

Mark your calendars—the 2014 tournament will be held Wednesday, June 18 at Granite Links!

For more information, please contact Sean Fairley or Brian Taranto.

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Events in Review

Winter Gathering at Back Bay Social Club
Winter Gathering at Back Bay Social Club – February 26, 2013
On February 26, DFLC members and guests attended the Winter Gathering. Thank you to inaugural DFLC Fellow Eli Van Allen, MD, who spoke about how the Council's support has impacted his research. Pictured left to right: Kathy Guilfoyle, Jim Weis, and Eli Van Allen, MD.

Rally Against CancerSMRally Against CancerSM– April 8, 2013
Congratulations to Council member Chris Carlin who served as the State Street Corporation Boston Rally Against Cancer team captain and was the top company, raising more than $59,000! We also thank DFLC Rally participants Amy Sullivan (Captain, Transamerica Retirement Solutions), Kristian Pearson, Jeff Goldstein (Captain, Boston Capital), Scott Sadowsky (Captain, Williams Distributing), Sarah Peach, Andy Fay, and Darby Stott (Captain, Fidelity Family Office Services).

Eaton Vance Rooftop ReceptionEaton Vance Rooftop Reception – May 9, 2013
On May 9, guests gathered at Eaton Vance for the 13th Annual Rooftop Reception and "Round Robin" program. Many thanks to Eaton Vance for once again hosting this special evening where attendees hear about the latest research and advances in patient care from six DFCI professionals. Thank you to the following Dana-Farber professionals for participating in this inspiring evening: David A. Barbie, MD; Kira Bona, MD; Douglas E. Brandoff, MD; Richard Boyajian, RN, NP; Ellen Casey-Magleby, MBA; and Nikhil Wagle, MD. Pictured left to right: Richard Boyajian, Ragu Adinarayanan, and Rachel Pearson.

Smith & WollenskyNew Member Dinner – June 26, 2013
On June 26, new members were invited to join Council leadership for an opportunity to get to know one another over dinner and drinks at Smith & Wollensky in the Back Bay. Thank you to Jeff Beale and Eaton Vance for hosting this wonderful event.

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Science Spotlight

molecular pathways

Cancer researchers often refer to abnormal "molecular pathways" that cause cells to run amok and form tumors. New "targeted" therapies are designed to block some of these pathways and force cells to die or stop misbehaving. But what is a pathway? Molecular or "signaling" pathways are networks of proteins that conduct a linear flow of information from the outer cell surface to the nucleus of the cell. Cells are like children: They need constant input and reminders from their environment on how to behave—when to grow, divide, stop growing, rest, and so on. These reminders come in the form of chemical signals such as hormones and growth factors. The signals stimulate receptor molecules on the cell surface, and the receptors in turn stimulate proteins within the cell that pass the message on to the next protein, and the next, until the message is received in the cell's nucleus. There, the message activates the DNA programs that tell the cell how to act. These pathways and networks are dizzyingly complex, comprising thousands of interacting proteins. An error or mutation in just one protein can cause disastrous miscommunication, leading to diseases like cancer, diabetes, or autoimmune disorders. Mutations in certain pathways allow cancer cells to ignore messages from their environment and grow out of control; such cells may also invade normal tissues, recruit new blood vessels for nourishment, evade the immune system, and defy orders to self-destruct. That's why a major thrust of cancer research is aimed at identifying cancer-related disruptions in molecular pathways and discovering or creating drugs that block those abnormal pathways but don't affect normal pathways in healthy cells.

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Dana-Farber in the News

Julia Hayes, MDObservation Safe in Some Prostate Cancer
Dana-Farber researchers, led by Julia Hayes, MD, find many men with low-risk, localized prostate cancers can safely choose observation instead of undergoing immediate treatment. In some situations, it is a cost-saving alternative. Click here to learn more.

John Quackenbush, PhDWhite House: Dana-Farber's Quackenbush a 'Champion of Change'
The Obama administration recognizes Dana-Farber's John Quackenbush, PhD, as an Open Science Champion of Change for his contributions to the larger research community. Click here to learn more.

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Dana-Farber Cancer Institute The 
Jimmy Fund

Dana-Farber Cancer Institute
Division of Development & The Jimmy Fund
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Brookline, MA 02445-7226

© 2013 Dana-Farber Cancer Institute and the Jimmy Fund